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Joaquin Phoenix

Larry "Doc" Sportello

Josh Brolin

Lt. Det. Christian F. "Bigfoot" Bjornsen

Owen Wilson

Coy Harlingen

Katherine Waterston

Shasta Fay Hepworth

Reese Witherspoon

Deputy D.A. Penny Kimball

Benicio del Toro

Sauncho Smilax, Esq.

Jena Malone

Hope Harlingen

Joanna Newsom

Sortilège, who is also the narrator

Jordan Christian Hearn

Denis

Hong Chau

Jade

Jeannie Berlin

Aunt Reet

Maya Rudolph

Petunia Leeway

Michael Kenneth Williams

Tariq Khalil

Martin Short

Dr. Rudy Blatnoyd, D.D.S.

Sasha Pieterse

Japonica Fenway

Martin Donovan

Crocker Fenway

Eric Roberts

Michael Z. "Mickey" Wolfmann

Serena Scott Thomas

Sloane Wolfmann

Christopher Allen Nelson

Glenn Charlock

Sam Jaeger

Agent Flatweed

Timothy Simons

Agent Borderline

Jillian Bell

Chlorinda

Taylor Bonin

Ensenada Slim

Martin Dew

Dr. Buddy Tubeside

Shannon Collis

Bambi

Catherine Haena Kim

News Reporter

Vivienne Khaledi

Amethyst Harlingen

Yvette Yates Redick

Luz

Andrew Simpson

Riggs Warbling

Joe Dioletto

Cop with Bigfoot

Jack Kelly

Burke Stodger (archive footage)

Belladonna

Clancy Charlock

Alina Gatti

Howdy Doper's Phone Voice (voice)

Elaine Tan

Xandra

Wilson Bethel

LAPD Officer #1

Anders Holm

LAPD Officer #2

Emmet Unverzagt

Bigfoot's Kid

Erica Sullivan

Dr. Lily Hammer

Eva Fisher

Dr. Threeply's Assistant #1

Jackie Michele Johnson

Dr. Threeply's Assistant #2

Katie Schwartz

Kimberly

Charley Morgan

Dr. Igor

Keith Jardine

Puck Beaverton

Delaina Mitchell

Mrs. Chastity Bjornsen

Michael Cotter

Rhus Frothingham

Peter McRobbie

Adrian Prussia

Shannon C. Sullivan

Adrian Prussia's Secretary

Samantha Lemole

Golden Fang Mother

Madison Leisle

Golden Fang Daughter

Liam Van Joosten

Golden Fang Son

Matt Doyle

Golden Fang Father

Christian Williams

Smedley

Jefferson Mays

Dr. Threeply

David Prak

Buddhist Monk

Amy Ferguson

Bodhi

Emma Dumont

Zinnia

Scott Aschenbrenner

Jesus Guard (uncredited)

Christina Bobrowsky

Patient (uncredited)

Peter Bonilla

Police Officer (uncredited)

Gregoer Boru

Recording Tech (uncredited)

Marianne Bourg

Beach Girl (uncredited)

Toyia Brown

Harmony (uncredited)

Stu Brumbaugh

Groupie (uncredited)

Seth Cash

Detective (uncredited)

Laura Lyon Rossi

Groupie (uncredited)

Ashleigh Biller

Patient (uncredited)

Elizabeth Colunga

Patient (uncredited)

Emma Cooper

Groupie (uncredited)

Nick de Graffenreid

Patient (uncredited)

Adam Dorsey

Jesus Guard (uncredited)

Ken Edling

Judge (uncredited)

Jenna Emery

Groupie (uncredited)

Al Function

Biker (uncredited)

Brandy Futch

Flight Attendant (uncredited)

Lauren Goncher

Dental Assistant (uncredited)

Ellen Ho

Chinese Waitress (uncredited)

Jessica Huss

Speed Freak (uncredited)

Robert Peoples

Patient (uncredited)

Dallas James

Auto Mechanic (uncredited)

Christopher Karl Johnson

Mr. Robinson (uncredited)

Timothy Lally

Commando (uncredited)

Adeana Lane

Beach Girl (uncredited)

Kira Legg

Groupie (uncredited)

Tracy Ann Lisa

District Attorney (uncredited)

Blue LoLan

Patient (uncredited)

Jacob Lyman

Mormon FBI Agent (uncredited)

Amanda Maddox

Flight Attendant (uncredited)

Emilee Madrak

Groupie (uncredited)

Kirstin Masters

Dental Assistant (uncredited)

Zach McMahon

Police Officer (uncredited)

Chelsea O'Toole

Patient (uncredited)

Shaun Parker

Commando (uncredited)

Rodney J. Richards

Adrian Prussia's Friend (uncredited)

Philip Roosevelt

Hippie in Commune (uncredited)

Osamu Saito

Japanese Waiter (uncredited)

Joel Shock

Police Officer (uncredited)

Matthew Skomo

Detective (uncredited)

Chantal Thuy

Groupie (uncredited)

Diana Elizabeth Torres

Lourdes (uncredited)